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The YS3 Delivery System pairs arginine with azelaic acid and salicylic acid. Arginine acts as a molecular carrier — the component that allows the system to pass the skin’s surface and draw the other actives with it. Most acne treatments work on the skin’s surface and strip the barrier in the process. The YS3 Delivery System passes the same surface without stripping it.
The result: azelaic acid, salicylic acid, and arginine reach where they can contribute to a clearer, calmer appearance of skin, without disrupting the barrier they passed through.
The YS3 Delivery System carries azelaic acid, salicylic acid, and arginine past the skin's surface, for clearer-looking skin, without stripping the barrier.
Including a method patent on post-inflammatory hyperpigmentation. No other brand in the acne and PIH space holds a comparable patent.
Most acne treatments disrupt the skin barrier to deliver actives. The YS3 Delivery System was designed to carry actives past the skin’s surface without the disruption. The result is built into the delivery.
Hydroquinone is the standard treatment for dark marks. The YS3 Delivery System addresses the appearance of post-inflammatory hyperpigmentation without it.
As an endodontist, Dr. Robert Nagel spent a lot of time watching topical anesthetic carry a precisely sized molecule through gum tissue to reach the nerve below. The principle — delivering an active past a biological barrier without disrupting it — was already proven in dentistry. He only need to figure out how to apply it to skin.
He spent years developing the system, working out how to pair arginine with azelaic acid and salicylic acid, and how to size the molecules correctly to pass the skin's surface without stripping the barrier. The result was the YS3 Delivery System.
The YS3 Delivery System allows for clearer-looking skin without the barrier disruption that keeps most people running through the acne cycle. Arginine, once past the skin's surface, helps the barrier retain moisture rather than lose it, which is why non-drying appears in more than 1,000 reviews. The outcome is built into the delivery.
The system began with a 2011 priority filing, and three US patents have been granted since, US10,202,338, US11,021,440, and US12,071,397, including a method patent on post-inflammatory hyperpigmentation. No other brand in the acne and PIH space holds a comparable patent.
Hydroquinone is banned for cosmetic use across much of Europe and linked to rebound darkening on melanin-rich skin. The YS3 Delivery System is designed to carry its actives past the skin’s surface for a more even-looking skin tone, without hydroquinone. One system, for the appearance of clearer skin and more even tone.
Peptide Blend is a natural amino acid derived from high-protein foods and plants. Increases trans-epidermal absorption, and penetrates the skin’s protective barrier to help the skin’s moisture level by naturally locking in water at the surface.
A multi-beneficial active derived from grain, it possesses an anti-bacterial action that actively reduces acne-causing bacteria and blocks the formation of abnormal pigment caused by skin inflammation resulting from acne, sun damage, and environmental irritants.
Derived from willow bark, salicylic acid breaks down the keratin in surface skin cells that can make skin look dull and congested. The result is the appearance of visibly clearer, more refined-looking skin over time.
One of the most potent antioxidants available in skincare, astaxanthin reduces oxidative damage caused by environmental stressors. Contributes to the appearance of younger-looking, more even-toned skin.
A polysaccharide that supports the skin barrier’s integrity and helps it retain moisture. Contributes to the appearance of a healthier, more resilient-looking barrier and smoother-feeling skin.
Known for its calming properties, Chamomilla recutita contributes to the appearance of less reactive, more comfortable-looking skin. Particularly effective for skin that appears red or sensitized after exposure to actives.
Glabridin is the active brightening compound derived from licorice root. It contributes to the appearance of a more even-looking complexion by addressing the look of dark spots and areas of uneven tone.
A naturally occurring molecule that binds water to the skin’s surface. Contributes to the appearance of more hydrated, plumper-looking skin and supports the barrier’s ability to retain moisture throughout the day.
A stable, oil-soluble derivative of kojic acid that contributes to the appearance of a brighter, more even-looking complexion. More stable than kojic acid in its standard form, making it effective over the full shelf life of the product.
Contributes to the appearance of a more even-looking skin tone. Works alongside Glabridin, the active compound also derived from licorice root, to support a brighter-looking complexion over time.
A carotenoid antioxidant derived from plants that reduces oxidative damage at the skin’s surface. Contributes to the appearance of younger-looking, more even-toned skin with continued use.
A targeted peptide developed specifically to address the appearance of dark spots and uneven skin tone. Works to support a more even-looking complexion over time, making it one of the key actives in the Fade + Brighten Hyperpigmentation Serum.
A lightweight, non-comedogenic emollient that softens the skin’s surface without clogging pores. Contributes to the appearance of smoother, more nourished-looking skin.
A highly stable emollient that mirrors the skin’s own natural lipids. Helps the skin’s surface feel softer and more balanced without leaving a heavy or greasy feel.
Contributes to the appearance of cleaner, clearer-looking skin. Known for its purifying properties at the skin’s surface, making it a supporting active in formulas targeting the appearance of blemishes.
A fat-soluble antioxidant that protects the skin’s surface from oxidative damage and supports the integrity of the barrier. Contributes to the appearance of healthier, more even-looking skin with continued use.
The natural source of salicylic acid, willow bark extract contributes to clearer-looking skin by supporting the removal of surface skin cells that can make the complexion look dull. Works alongside salicylic acid in the formula for a compounding effect on skin clarity.
Azelaic acid, salicylic acid, arginine — chosen for what they contribute to the appearance of clearer, calmer skin. Selected after the delivery system was designed, not before. Every other acne brand started with an ingredient. Evologie started with the delivery. That sequence is the difference.
